学術論文

セラミド基盤研究

2024

Efficacy of Pseudo-Ceramide Absorption Into the Stratum Corneum and Effects on Transepidermal Water Loss and the Ceramide Profile: A Randomized Controlled Trial

Journal of Cosmetic Dermatology
Vol.24, e16655

2023

Chain length of covalently bound ceramides correlates with skin barrier function in healthy subjects

Journal of Dermatological Science, Vol.110, No.1, 35-38

2005

Characterization of surfactant-induced skin damage through barrier recovery induced by pseudoacylceramides

Dermatology Vol.211, No.2, 128-134

2004

Reevaluation of the importance of barrier dysfunction in the nonlesional dry skin of atopic dermatitis patients through the use of two barrier creams

Exogenous Dermatology Vol.3, No.6, 293-302

2004

Surfactant-induced depletion of ceramides and other intercellular lipids: Implication for the mechanism leading to dehydration of the stratum corneum

Exogenous Dermatology Vol.3, No.2, 81-98

2004

Decreased levels of covalently bound ceramide are associated with ultraviolet B-induced perturbation of the skin barrier

Journal of Investigative Dermatology Vol.123, No.6, 1102-1109

1991

Stratum corneum lipids serve as a bound-water modulator

Journal of Investigative Dermatology Vol.96, No.6, 845-851

1991

Decreased level of ceramides in stratum corneum of atopic dermatitis: An etiologic factor in atopic dry skin?

Journal of Investigative Dermatology Vol.96, No.4, 523-526

1989

Functions of lipids on human skin

Journal of Dispersion Science and Technology Vol.10, No.4-5, 617-641

1989

Water-retaining function in the stratum corneum and its recovery properties by synthetic pseudoceramides

Journal of the Society of Cosmetic Chemists Vol.40, No.5, 273-285

1989

Importance of intercellular lipids in water-retention properties of the stratum corneum: induction and recovery study of surfactant dry skin

Archives of Dermatological Research Vol.281, No.1, 45-51

1986

Selective recovery of deranged water-holding properties by stratum corneum lipids

Journal of Investigative Dermatology Vol.87, No.6, 758-761

1985

A possible function of structural lipids in the water-holding properties of the stratum corneum

Journal of Investigative Dermatology Vol.84, No.4, 282-284

セラミド・敏感肌基盤研究

2025

「日本アレルギー学会 2025年度サノフィ優秀論文賞」受賞


Altered Ceramide Profile of Facial Sensitive Skin: Disordered Intercellular Lipid Structure Is Linked to Skin Hypersensitivity

Journal of Cosmetic Dermatology
Vol.24, e70154

Increased Unsaturation of Fatty Acids in Covalently Bound Ceramides Is Linked to Disordered Intercellular Lipid Structure and Skin Hypersensitivity

Journal of Cosmetic Dermatology
Vol.24, e70489

2023

「日本研究皮膚科学会 第24回マルホ研究賞」受賞


2022

Stratum Corneum Ceramide Profiles Provide Reliable Indicators of Remission and Potential Flares in Atopic Dermatitis

Journal of Investigative Dermatology Vol.142,No.12,3184-3191

2022

Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial

Journal of Cosmetic Dermatology Vol.21,No.10,4503-4509

2020

The ceramide [NP]/[NS] ratio in the stratum corneum is a potential marker for skin properties and epidermal differentiation

BMC Dermatology Vol.20, No.6

2020

Treatment with Synthetic Pseudoceramide Improves Atopic Skin, Switching the Ceramide Profile to a Healthy Skin Phenotype

Journal of Investigative Dermatology Vol.140, No.9, 1762-1770

2019

UVB sensitivity correlates with cutaneous barrier function in the skin of Japanese females

Photodermatology, Photoimmunology & Photomedicine Vol.35, No.4, 284-285

2013

Dry skin in the winter is related to the ceramide profile in the stratum corneum and can be improved by treatment with a Eucalyptus extract

Journal of Cosmetic Dermatology Vol.12, No.1, 3-11

2012

Eucalyptus increases ceramide levels in keratinocytes and improves stratum corneum function

International Journal of Cosmetic Science Vol.34, No.1, 17-22

2010

Comparison of skin barrier function and sensory nerve electric current perception threshold between IgE-high extrinsic and IgE-normal intrinsic types of atopic dermatitis

British Journal of Dermatology Vol.162, No.1, 83-90

2010

Changes in the ceramide profile of atopic dermatitis patients

Journal of Investigative Dermatology Vol.130, No.10, 2511-2514

2009

Comprehensive quantification of ceramide species in human stratum corneum

Journal of Lipid Research Vol.50, No.8, 1708-1719

2008

Characterization of overall ceramide species in human stratum corneum

Journal of Lipid Research Vol.49, No.7, 1466-1476

セラミド機能成分*有効性評価
*ヘキサデシロキシPGヒドロキシエチルヘキサデカナミド

2025

Biological effects of a fine fiber film treated with a lotion to improve dry skin

Skin Research and Technology,  Vol.31, No.2-5, e70161

2022

Usefulness of a synthetic ceramide containing moisturizing spray to maintain remission of atopic dermatitis

Aesthetic Dermatology Vol.32,18-27

2022

Washing with a body cleanser and topical application of a moisturizer containing a pseudo-ceramide and a eucalyptus extract are effective to improve mild atopic dermatitis in Thailand

Journal of Cosmetic Dermatology Vol.21, No.11, 6443–6445

2021

Rubbing the skin when removing makeup cosmetics is a major factor that worsens skin conditions in atopic dermatitis Patients

Journal of Cosmetic Dermatology Vol.20,  No.6, 1915–1922

2021

The efficacy of synthetic pseudo-ceramide for dry and rough lips

International Journal of Cosmetic Science, Vol.43, 158–164

2020

擬似セラミドをラメラ状にして配合したクリームのアトピー性皮膚炎患者に対する有用性評価

Aesthetic Dermatology Vol.30, No.3, 261-270

2019

Efficacy of a moisturizer containing a pseudo-ceramide and a eucalyptus extract for Japanese patients with mild atopic dermatitis in the summer

Journal of Cosmetic Dermatology Vol.18, No.3, 850-856

2018

The efficacy of a lip balm containing pseudo-ceramide on the dry lips of sensitive skin-conscious subjects

Journal of Cosmetic Dermatology Vol.17, No.1, 84-89

2018

The efficacy of a pseudo-ceramide and eucalyptus extract containing lotion on dry scalp skin

Clinical, Cosmetic and Investigational Dermatology Vol.11, 141-148

2018

Amelioration of lactic acid sensations in sensitive skin by stimulating the barrier function and improving the ceramide profile

Archives of Dermatological Research Vol.310, No.6, 495-504

2017

Subclinical cutaneous inflammation remained after permeability barrier disruption enhances UV sensitivity by altering ER stress responses and topical pseudoceramide prevents them

Archives of Dermatological Research Vol.309, No.7, 541-550

2015

Efficacy of the combined use of a facial cleanser and moisturizers for the care of mild acne patients with sensitive skin

Journal of Dermatology Vol.42, No.2, 181-188

2014

Evaluation of a Pseudoceramide Moisturizer in Patients with Mild-to-Moderate Atopic Dermatitis

Dermatology and Therapy(Heidelb) Vol.4, No.1, 83–92

2011

Pseudo-ceramide for childhood eczema: does it work?

Hong Kong Medical Journal Vol.17, No.2, 132-136

2009

Efficacy and safety of pseudo-ceramide containing moisture cream in the treatment of senile xerosis

Hong Kong Journal of Dermatology and Venereology Vol.17, No.4, 181-184

2006

アトピックドライスキンにおけるバリアー障害の回復の意義

西日本皮膚科 Vol.68, No.4, 413-421

2004

Recharacterization of the nonlesional dry skin in atopic dermatitis through disrupted barrier function

Exogenous Dermatology Vol.3, No.6, 282-292

2004

新生児・乳幼児に対するスキンケア及び洗浄製品の使用試験

日本小児皮膚科学会誌 Vol.23, No.2, 247-258

2004

合成擬似セラミド配合全身ローション(KO401)の有用性と安全性の検討

臨牀と研究 Vol.81, No.12, 2039-2049

2002

アトピー性皮膚炎に対する合成疑似セラミド含有クリームの有用性の検討 —尿素含有クリームとの比較—

西日本皮膚科 Vol.64, No.5, 606-611

2001

アトピー性皮膚炎患者に対する合成擬似セラミド含有クリームの有用性の検討

西日本皮膚科 Vol.4, No.63, 457-461

2000

アトピックドライスキンに対するスキンケア製品の使用経験

皮膚別冊 Vol.42, No.2, 264-269

1999

アトピー性皮膚炎患者に対する合成擬似セラミドクリームの有用性および安全性の検討

西日本皮膚 Vol.61, No.5, 671-681

総説その他

総説

2025

敏感肌の皮膚生理とセラミドの関係性

オレオサイエンス Vol.25, No.9, 379-387

2021

乾燥に起因するかゆみに対する保湿剤の有用性-皮膚バリア機能改善とセラミドプロファイルの変化

フレグランスジャーナル Vol.49, No.12, 32-38

2021

乾燥皮膚のかゆみに対するスキンケア保湿剤の有用性

Medical Science Digest Vol 47, No.4, Industry News

2021

セラミドに着目した敏感肌のスキンケア

日本香粧品学会誌 Vol45, No3, 201-208

2021

角層バリア機能の紫外線感受性に対する影響ーセラミドケアによる紫外線防御ー

進化する皮膚科学 pp.341-349

2020

マイクロミキサーで混ぜる -ミリ秒高速混合を利用した新規ナノ乳化技術

化学と工業 Vol.73, No.5, 405-407

2019

敏感肌研究

フレグランスジャーナル Vol.47, No.5, 42-47

2016

敏感肌とは何か?

Bella Pelle Vo.1, No.2, 90-93

2013

洗浄料の皮膚への影響と敏感肌のための低刺激洗浄技術

Cosmetic Stage Vol.8, No.1, 1-7

2011

敏感肌ー意識・実態とスティンギング(刺激感)

日本香粧品学会誌 Vo.35, No.2, 107-112

2011

ヒト角層・毛髪におけるセラミド分子網羅解析技術の開発

フレグランスジャーナル Vol.39,No.7,17-24

2011

アトピー性皮膚炎におけるセラミドケアの重要性(2)

アレルギーの臨床 Vol.31, No.2, 60-66

2010

アトピー性皮膚炎におけるセラミドケアの重要性

アレルギーの臨床 Vol.30, No.13, 50-55

2007

保湿のメカニズムと頭皮ケア

皮膚と美容 Vol.39, No.4, 214-219

2006

こどものスキンケア -スキンケア製品

小児看護 Vol.29, No.10, 1355-1378

2006

化粧品の機能について 敏感肌用化粧品

Visual Dermatology Vol.5, No.5, 442-445

2005

アトピー性皮膚炎患者と対象とした化粧品の効用

Visual Dermatology Vol.4, No.12, 1224-1225

著書(共著):本の一章

2025

敏感肌のセラミドケア研究

酒皶・敏感肌 pp.169-173

2015

Atopic dermatitis (AD) and lipids

Lipids and Skin Health pp.343-356

2001

Ceramides as natural moisturizing factors and their efficacy in dry skin

Skin Moisturization pp.267-302
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